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ЖУРНАЛЫ // Письма в Журнал экспериментальной и теоретической физики // Архив

Письма в ЖЭТФ, 2011, том 93, выпуск 1, страницы 43–1 (Mi jetpl1802)

Эта публикация цитируется в 1 статье

БИОФИЗИКА

Are the complex distributed genetic networks inherently oscillatory and chaotic?

V. P. Zhdanovab

a Boreskov Institute of Catalysis RAS, 630090 Novosibirsk, Russia
b Department of Applied Physics, Chalmers University of Technology, S-412 96 Göteborg, Sweden

Аннотация: Complex mRNA-protein networks with distributed regulation of gene transcription are often mimicked by random Boolean networks. According to this mapping, the gene-expression kinetics are expected to depend strongly on the network connectivity, $m$. Specifically, the kinetics are predicted to be oscillatory or chaotic for $m>2$. We analyze this problem in more detail by using an accurate model explicitly describing the mRNA-protein interplay with randomly organized transcriptional regulation. Contrary to the expectations, our mean-field calculations and Monte Carlo simulations performed for $m=1$, $2$ and $4$ show that oscillations and chaos are lacking irrespective of $m$.

Поступила в редакцию: 16.11.2010

Язык публикации: английский


 Англоязычная версия: Journal of Experimental and Theoretical Physics Letters, 2011, 93:1, 41–45

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