M. I. Lavrov, O. V. Stroganov, V. L. Zamoyski, V. V. Grigoriev, M. E. Zapolskiy, S. V. Sysolyatin, V. V. Malykhin, V. N. Surmachev, V. A. Palyulin, “Synthesis of an allosteric modulator of ionotropic glutamate receptors”, Mendeleev Commun., 2020, том 30, выпуск 2,страницы 156–158

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Mendeleev Commun., 2020, том 30, выпуск 2, страницы 156–158 (Mi mendc1132)

Эта публикация цитируется в 7 статьях

Synthesis of an allosteric modulator of ionotropic glutamate receptors

M. I. Lavrov^ab, O. V. Stroganov^cd, V. L. Zamoyski^b, V. V. Grigoriev^ab, M. E. Zapolskiy^d, S. V. Sysolyatin^e, V. V. Malykhin^e, V. N. Surmachev^e, V. A. Palyulin^ab

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^c N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^d QM Pharma LLC, Skolkovo Innovation Center, Moscow, Russian Federation
^e Institute for Problems of Chemical & Energetic Technologies, Siberian Branch of the Russian Academy of Sciences, Biysk, Russian Federation

Аннотация: Synthesis of 6-[4-methoxy-3-(pyrrolidin-1-ylmethyl)benzyl]-1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione has been carried out and optimized. In vitro studies using electrophysiological patch clamp technique have revealed a negative effect of this compound on kainateinduced currents in Purkinje neurons in a wide range of concentrations from 10–11 to 10–6 m.

Ключевые слова: 3,7-diazabicyclo[3.3.1]nonane, AMPA receptor, negative allosteric modulator, NAM, patch clamp.

Язык публикации: английский

DOI: 10.1016/j.mencom.2020.03.008

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