G. N. Kadikova, V. A. D'yakonov, R. N. Nasretdinov, L. U. Dzhemileva, U. M. Dzhemilev, “Synthesis of new alkynyl containing 9-azabicyclo[4.2.1]nonatrienes from diynes and azepines”, Mendeleev Commun., 2020, том 30, выпуск 3,страницы 318

Эта публикация цитируется в 7 статьях

Synthesis of new alkynyl containing 9-azabicyclo[4.2.1]nonatrienes from diynes and azepines

G. N. Kadikova, V. A. D'yakonov, R. N. Nasretdinov, L. U. Dzhemileva, U. M. Dzhemilev

Institute of Petrochemistry and Catalysis, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation

Аннотация: New 7-alkynyl-9-azabicyclo[4.2.1]nona-2,4,7-triene-9-carboxylates were obtained upon the Co(acac)2(dppe)/Zn/ZnI2-catalyzed [6p+2p]-cycloaddition of 1,3-diynes to ethyl/phenyl azepine-1-carboxylates. The structures of the obtained azacyclic compounds were established by 1D and 2D NMR spectroscopy. The compounds prepared were tested for antitumor activities in vitroagainst Jurkat, K562, U937 and HL60 cancer cell lines.

Ключевые слова: cycloaddition, catalytic systems, azepine-1-carboxylates, 1,3-diynes, 9-azabicyclo[4.2.1]nona-2,4,7-trienes, cobalt complexes, antitumor activity.

Язык публикации: английский

DOI: 10.1016/j.mencom.2020.05.019