S. Gundala, M. R. Guda, A. F. Khasanov, D. S. Kopchuk, A. P. Krinochkin, S. Santra, G. V. Zyryanov, P. Venkatapuram, J. R. Garcia, V. N. Charushin, “A PASE-based approach towards 12-(1H-1,2,3-triazol-1-yl)-indolo[2,1-a]isoquinolines via the reaction of 3-(isoquinolin-1-yl)-1,2,4-triazines with benzyne”, Mendeleev Commun., 29:4 (2019), 369

Эта публикация цитируется в 9 статьях

Communications

A PASE-based approach towards 12-(1H-1,2,3-triazol-1-yl)-indolo[2,1-a]isoquinolines via the reaction of 3-(isoquinolin-1-yl)-1,2,4-triazines with benzyne

S. Gundala^ab, M. R. Guda^ac, A. F. Khasanov^ad, D. S. Kopchuk^ad, A. P. Krinochkin^ad, S. Santra^a, G. V. Zyryanov^ad, P. Venkatapuram^b, J. R. Garcia^c, V. N. Charushin^ad

^a Institute of Chemical Engineering, Ural Federal University, Ekaterinburg, Russian Federation
^b Department of Chemistry, Sri Venkateswara University, Andhra Pradesh, India
^c Departamento de Química, Universidade Estadual de Ponta Grossa, Paraná, Brazil
^d I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation

Аннотация: 12-(1H-1,2,3-Triazol-1-yl)indolo[2,1-a]isoquinolines are prepared in 51–56% yields using a PASE (pot, atom, step, economic)-based approach, namely, by the reaction between available 5-R-6-Ar-3-(isoquinolin-1-yl)-1,2,4-triazines and in situ generated benzyne. A mechanism comprising domino-transformation was suggested, and the structure of one key product was confirmed by a single crystal X-ray diffraction analysis.

Язык публикации: английский

DOI: 10.1016/j.mencom.2019.07.002

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