RUS  ENG
Полная версия
ЖУРНАЛЫ // Mendeleev Communications // Архив

Mendeleev Commun., 2024, том 34, выпуск 4, страницы 514–517 (Mi mendc171)

Communications

New pyridine dithiaazacrown ether derivatives: synthesis, structural characterization, in silico and in vitro biological studies

V. T. T. Trana, N. T. Daoa, T. T. Doa, T. T. T. Phamb, D. T. Lea, V. N. Khrustalevcd, Ph. T. T. Nguyene, A. T. Lea

a Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, Hoan Kiem, Hanoi, Vietnam
b Faculty of Pharmacy, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen City, Vietnam
c Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation
d N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
e Department of Training, FPT University, Hanoi, Vietnam


Аннотация: New derivatives of dithiaazacrown ethers containing ψ-arylpyridine subunits were prepared based on the Hantzsch synthesis. The obtained compounds showed potential activities toward Hep-G2 cancer cell line, in both in silico and in vitro studies. The compounds were also good ligands for complex chemistry with metal ions due to possessing up to four heteroatoms and relatively big size of the crown ring.

Ключевые слова: dithiaazacrown ethers, arylpyridine subunit, Hantzsch synthesis, Hep-G2, crown ring.

Язык публикации: английский

DOI: 10.1016/j.mencom.2024.06.014



© МИАН, 2025