G. A. Chesnokov, P. S. Gribanov, M. A. Topchiy, L. I. Minaeva, A. F. Asachenko, M. S. Nechaev, E. V. Bermesheva, M. V. Bermeshev, “Solvent-free Buchwald–Hartwig amination with low palladium loadings”, Mendeleev Commun., 2017, том 27, выпуск 6,страницы 618

Эта публикация цитируется в 22 статьях

Solvent-free Buchwald–Hartwig amination with low palladium loadings

G. A. Chesnokov^a, P. S. Gribanov^b, M. A. Topchiy^b, L. I. Minaeva^c, A. F. Asachenko^bc, M. S. Nechaev^ab, E. V. Bermesheva^ad, M. V. Bermeshev^b

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russian Federation
^c Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation
^d I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation

Аннотация: A highly efficient ‘green’ solvent-free monoarylation of primary anilines with aryl bromides mediated by the expanded-ring N-heterocyclic carbene palladium complex (THP-Dipp)Pd(cinn)Cl [THP-Dipp is 1,3-bis(2,6-diisopropylphenyl)- 3,4,5,6-tetrahydropyrimidin-2-ylidene; cinn is cinnamyl] can be performed at low catalyst loadings (0.1 mol%) to provide excellent yields and remarkable selectivities for various substrates.

Ключевые слова: N-heterocyclic carbene palladium catalysts, solvent-free reactions, cross-coupling, amination.

Язык публикации: английский

DOI: 10.1016/j.mencom.2017.11.027