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ЖУРНАЛЫ // Mendeleev Communications // Архив

Mendeleev Commun., 2016, том 26, выпуск 5, страницы 388–390 (Mi mendc2222)

Эта публикация цитируется в 17 статьях

Communications

Ionic liquid supported 4-HO-Pro-Val derived organocatalysts for asymmetric aldol reactions in the presence of water

A. S. Kucherenkoa, V. V. Perepelkina, G. M. Zhdankinaa, G. V. Kryshtala, E. Srinivasanb, H. Inanib, S. G. Zlotina

a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
b School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Rajasthan, India


Аннотация: Novel $(\mathrm{4}{R})\text{-}\mathrm{HO}\text{-}(\mathrm{2}S)\text{-}\mathrm{Pro}\text{-}(S)\text{-}\mathrm{Val}$ derivative tagged to 1-methylimidazolium cation and $\mathrm{PF_6^-}$ anion efficiently catalyzes asymmetric aldol reactions of cyclic ketones with aromatic aldehydes in aqueous environment to afford the corresponding aldols in high yield with moderate to high anti-diastereo- (dr up to 99:1) and enantioselectivity (up to 98% ee). The catalyst was recycled 9 times in the same reaction without any decrease in selectivity values.

Язык публикации: английский

DOI: 10.1016/j.mencom.2016.09.007



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