K. E. Shepelenko, I. G. Gnatiuk, A. A. Aleksandrov, M. E. Minyaev, V. M. Chernyshev, “Regioselective arylation of (het)aryl fragment in 2-(het)aryl-1-methylperimidines under ruthenium catalysis ”, Mendeleev Commun., 34:6 (2024), 875

Communications

Regioselective arylation of (het)aryl fragment in 2-(het)aryl-1-methylperimidines under ruthenium catalysis

K. E. Shepelenko^a, I. G. Gnatiuk^a, A. A. Aleksandrov^a, M. E. Minyaev^b, V. M. Chernyshev^a

^a Platov South-Russian State Polytechnic University, Novocherkassk, Russian Federation
^b N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Аннотация: The ruthenium-catalyzed reaction of 2-(het)aryl-1-methylperimidines with aryl bromides proceeds as regioselective C–H ortho-arylation of the (het)aryl fragment, perimidine core acting as a directing group. The reaction is selective and tolerates to different functional groups in aryl bromide thus allowing further functionalization of the obtained products.

Ключевые слова: ruthenium catalysis, CH-activation, arylation, perimidines, furan, thiophene.

Язык публикации: английский

DOI: 10.1016/j.mencom.2024.10.033

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