A. M. Inshakova, V. A. Shchelkonogov, N. S. Shastina, A. V. Chekanov, O. A. Baranova, M. O. Sokolova, A. K. Ivanova, A. I. Fedin, E. Yu. Solov'eva, “Antioxidant and antiplatelet effect of nanodispersions with conjugate of glutathione and lipoic acid”, Mendeleev Commun., 34:6 (2024), 887

Communications

Antioxidant and antiplatelet effect of nanodispersions with conjugate of glutathione and lipoic acid

A. M. Inshakova^a, V. A. Shchelkonogov^ab, N. S. Shastina^a, A. V. Chekanov^b, O. A. Baranova^b, M. O. Sokolova^c, A. K. Ivanova^c, A. I. Fedin^b, E. Yu. Solov'eva^b

^a M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University, Moscow, Russian Federation
^b N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation
^c S.M. Kirov Military Medical Academy, St. Petersburg, Russian Federation

Аннотация: To increase the therapeutic effectiveness of antioxidants (lipoic acid and glutathione) and improve their transport to target cells, various methods of modifying its substances are used. In this work, the synthesis of an amide derivative of lipoic acid and glutathione (GSH–LA) is performed, and GSH–LA nanodispersions based on Pluronic F68 are obtained. The most pronounced antioxidant and antiplatelet effects are exhibited by nanoparticles containing GSH–LA at the maximum tested concentration.

Ключевые слова: nanodispersions, lipoic acid, glutathione, neutrophils, platelets.

Язык публикации: английский

DOI: 10.1016/j.mencom.2024.10.037

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