O. N. Zefirova, E. V. Nurieva, V. I. Chupakhin, I. S. Semenova, D. I. Peregud, M. V. Onufriev, N. V. Gulyaeva, “Design, synthesis and biotest of a bicyclo[3.3.1]nonane analogue of 2-amino-5,6-dihydro-4H-1,3-thiazine”, Mendeleev Commun., 20:6 (2010), 323

Эта публикация цитируется в 18 статьях

Design, synthesis and biotest of a bicyclo[3.3.1]nonane analogue of 2-amino-5,6-dihydro-4H-1,3-thiazine

O. N. Zefirova^ab, E. V. Nurieva^a, V. I. Chupakhin^b, I. S. Semenova^a, D. I. Peregud^c, M. V. Onufriev^d, N. V. Gulyaeva^d

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^c National Research Center on Addictions, Ministry of Health and Social Development of the Russian Federation, Moscow, Russian Federation
^d Institute for Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russian Federation

Аннотация: To enhance the lipophilicity of the NO-synthase inhibitor 2-amino-5,6-dihydro-4H-1,3-thiazine, its bridgehead analogue was suggested on the basis of molecular modeling; the synthetic routes to new 3-thia-1-azabicyclo[3.3.1]nonane derivatives and the results of their biological testing are presented.

Язык публикации: английский

DOI: 10.1016/j.mencom.2010.11.007

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