R. S. Begunov, Yu. R. Aleksandrova, E. Yu. Yandulova, N. S. Nikolaeva, M. E. Neganova, “Synthesis and cytotoxicity of 7,8-dihalopyrido[1,2-a]benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue”, Mendeleev Commun., 33:2 (2023), 237

Эта публикация цитируется в 1 статье

Communications

Synthesis and cytotoxicity of 7,8-dihalopyrido[1,2-a]benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue

R. S. Begunov^a, Yu. R. Aleksandrova^b, E. Yu. Yandulova^b, N. S. Nikolaeva^b, M. E. Neganova^b

^a P.G. Demidov Yaroslavl State University, Yaroslavl, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation

Аннотация: An efficient synthesis of 8-bromo-7-chloropyrido[1,2-a]-benzimidazole-6,9-dione and its 1,2,3,4-tetrahydro analogue from N-(4-chloro-2-nitrophenyl)pyridinium chloride has been accomplished. The study for antitumour activity against cancer cell lines such as A549, SH-SY5Y, Hep-2, HeLa and MCF-7 revealed that the cytotoxic effect of the compounds obtained was several times higher than that of Mitomycin C.

Ключевые слова: pyrido[1,2-a]benzimidazole-6,9-diones, 2-bromo-3-chloro-1,4-benzoquinones, intramolecular reductive reactions, hetero- cyclization, flow-through catalytic hydrogenation, prooxidant activity, cytotoxicity.

Язык публикации: английский

DOI: 10.1016/j.mencom.2023.02.028

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