Synthesis of (S)-N-hydantoinoalkylglycoluriles by one-pot double cyclisation of chiral α,ω-diureido acids under the action of 4,5-dihydroxyimidazolidin-2-ones

The reaction of 4,5-dihydroxyimidazolidin-2-ones with chiral (S)-N,N’-dicarbamoyl-α,ω-amino acids occurs as one-pot double cyclisation under acid catalysis to give the corresponding glycoluriles with (S)-N-hydantoinoalkyl substituents.