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ЖУРНАЛЫ // Mendeleev Communications // Архив

Mendeleev Commun., 1999, том 9, выпуск 2, страницы 76–77 (Mi mendc4533)

Эта публикация цитируется в 9 статьях

Synthesis of fluorinated furo- and pyrrolo[3,4-b]quinoxaline 4,9-dioxides

S. K. Kotovskayaa, N. M. Perovaa, V. N. Charushina, O. N. Chupakhinb

a Department of Organic Chemistry, Urals State Technical University, Ekaterinburg, Russian Federation
b I. Ya. Postovsky Institute of Organic Synthesis, Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation

Аннотация: The reaction of 5,6-difluorobenzofuroxane 1 with ethyl acetoacetate in the presence of triethylamine results in the formation of 2-methyl-3-ethoxycarbonyl-6,7-difluoroquinoxaline 1,4-dioxide 2 which was converted consequently into the bromomethyl 3 and acetoxymethyl 4 derivatives; hydrolysis of the latter with hydrochloric acid gave furo[3,4-b]quinoxaline 4,9-dioxide 5. Compound 3 was transformed by the action of ammonia and primary alkyl amines into 2-substituted 1,3-dihydro-2H-pyrrolo[3,4-b]quinoxaline 4,9-dioxides 6 and further into the corresponding 6-amino compounds 7 and 8.

Язык публикации: английский

DOI: 10.1070/MC1999v009n02ABEH001056



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