V. V. Spiridonov, A. R. Lukmanova, D. V. Pozdyshev, A. A. Markova, Yu. L. Volodina, G. V. Golovina, V. V. Shakhmatov, V. A. Kuzmin, V. I. Muronetz, A. A. Yaroslavov, “Ionically cross-linked micro-sized hydrogels with encapsulated drug: structure, cell uptake kinetics and cytotoxicity”, Mendeleev Commun., 2023, том 33, выпуск 4,страницы 553

Эта публикация цитируется в 4 статьях

Ionically cross-linked micro-sized hydrogels with encapsulated drug: structure, cell uptake kinetics and cytotoxicity

V. V. Spiridonov^a, A. R. Lukmanova^b, D. V. Pozdyshev^c, A. A. Markova^d, Yu. L. Volodina^e, G. V. Golovina^d, V. V. Shakhmatov^d, V. A. Kuzmin^d, V. I. Muronetz^c, A. A. Yaroslavov^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Department of Materials Science, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^c A.N. Belozersky Research Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^d N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russian Federation
^e N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation

Аннотация: Micro-sized hydrogels synthesized by electrostatic crosslinking of anionic alginate with Ca2+ cations were additionally loaded with cationic fluorescent dye Rhodamine 6B or cationic antitumor antibiotic doxorubicin. Forming complexes with Ca2+ alginate hydrogels, doxorubicin retained or even reduced its toxicity to tumor and normal cells. The results can be used to design containers for the encapsulation and delivery of drugs and control their interaction with cells.

Ключевые слова: sodium alginate, cross-linked hydrogels, rhodamine, doxorubicin, intracell migration, cytotoxicity.

Язык публикации: английский

DOI: 10.1016/j.mencom.2023.06.036