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ЖУРНАЛЫ // Mendeleev Communications // Архив

Mendeleev Commun., 2022, том 32, выпуск 2, страницы 189–191 (Mi mendc609)

Эта публикация цитируется в 11 статьях

Communications

Novel mucoadhesive carriers based on alginate-acrylamide hydrogels for drug delivery

M. Yu. Gorshkova, L. V. Vanchugova, I. F. Volkova, I. V. Obydennova, I. L. Valuev, L. I. Valuev

A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russian Federation


Аннотация: New mucoadhesive two-component carriers for drug delivery based on synthetic acrylamide/diethylacrylamide and natural alginate hydrogels have been synthesized. The introduction of sodium alginate into polyacrylamide/ poly(diethylacrylamide) gels, followed by their crosslinking with metal ions, significantly changed structure and properties of hydrogels, such as swelling degree, drug capacity and drug release rate in physiological solution. The structure of the gels was characterized by FTIR spectroscopy and scanning electron microscopy.

Ключевые слова: two-component hydrogel, interpenetrating networks, polyacrylamide, poly(N, N-diethylacrylamide), sodium alginate, covalent network, ionic network, drug delivery system.

Язык публикации: английский

DOI: 10.1016/j.mencom.2022.03.012



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