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ЖУРНАЛЫ // Наносистемы: физика, химия, математика // Архив

Наносистемы: физика, химия, математика, 2019, том 10, выпуск 5, страницы 564–572 (Mi nano470)

Эта публикация цитируется в 2 статьях

CHEMISTRY AND MATERIAL SCIENCE

Cerium oxide nanoparticles provide radioprotective effects upon X-ray irradiation by modulation of gene expression

N. R. Popovaa, T. O. Shekunovab, A. L. Popova, I. I. Seleznevaa, V. K. Ivanovb

a Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, 142290, Russia
b Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia

Аннотация: Nanocrystalline cerium dioxide is known as a unique redox active nanomaterial. Cerium dioxide is considered as the basis for future biomedical preparations, including radioprotectors. In the framework of this study, we synthesized citrate-stabilized CeO$_{2}$ nanoparticles and carried out a comprehensive in vitro assessment of their radioprotective properties on a NCTC L929 murine fibroblast culture. It was shown that CeO$_{2}$ nanoparticles ensure the survival of murine fibroblasts, even after high-dose X-ray irradiation, reducing the number of dead cells in the culture and modulating the mRNA level of the key antioxidant enzymes — superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2). The results obtained confirm the potential for studying the properties of CeO$_{2}$ nanoparticles as basic materials for designing new efficient and safe preparations for protection against ionizing radiation.

Ключевые слова: cerium oxide nanoparticles, radioprotection, cytotoxicity, X-ray, ionizing radiation, fibroblasts.

PACS: 68.65.k, 81.20.n, 82.70.Dd, 87.80.-y

Поступила в редакцию: 22.06.2019
Исправленный вариант: 04.10.2019

Язык публикации: английский

DOI: 10.17586/2220-8054-2019-10-5-564-572



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