Study of stress relief and strain distribution in graphene films of biosensors for viral infections

The practical application of graphene-based biosensors for viral infections is largely hampered by the irreproducibility of their parameters, including the adsorption properties of graphene in biosensors. In this work, a new source of irreproducibility of biosensor parameters caused by the formation of a stress relief on the graphene surface was experimentally discovered. Monitoring the topography of the graphene surface using atomic force microscopy together with analysis of graphene deformation using Raman spectroscopy makes it possible to reject plates with stress relief and significantly increase the reproducibility of biosensor parameters.