Calcium activity of the retrosplenial cortex neurons during object and place recognition in mice

The retrosplenial cortex (RSC) plays a key role in the processes of spatial navigation and coding of spatial information. However, the participation of the RSC in encoding information about objects has been studied little. In this work, we used fiber-optic photometry to record RSC calcium activity in novel object and novel place recognition tasks. We have shown that at the moment of animal contact with the object, there is a decrease in the calcium activity of the RSC, regardless of the behavioral task. At the same time, the performance of another form of exploration behavior rearing, was not accompanied by a similar decrease in the activity of the RSC. Thus, we have shown a specific change in the activity of RSC during the object exploration in mice.