K. A. Toropova, O. I. Ivashkina, A. A. Ivanova, E. V. Konovalova, K. V. Anokhin, “The e ects of traumatic experience on the behavior, c-fos expression and functional connections in the mouse brain resting state network”, Intelligent systems. Theory and applications, 2022, Volume 26, Issue 1,Pages <nobr>351

Part 7. Neuromorphic artificial intelligence and cognitive systems

The e ects of traumatic experience on the behavior, c-fos expression and functional connections in the mouse brain resting state network

K. A. Toropova^ab, O. I. Ivashkina^ba, A. A. Ivanova^ac, E. V. Konovalova^d, K. V. Anokhin^b

^a NRC «Kurchatov Institute»
^b Institute of Advanced Brain Studies of Lomonosov MSU
^c Institute of Higher Nervous Activity and Neurophysiology of RAS
^d Research Institute of Normal Physiology named after P.K. Anokhin

Abstract: In this study we investigated the in uence of post-traumatic stress disorder on spontaneous behavior and resting state brain activity of animals. Using automated behavior analysis, Fos-neuroimaging and rest network mapping, we showed stressful experiences can alter spontaneous behavior, induced and spontaneous brain activity and patterns of functional connections in resting state neuronal networks long after trauma.

Keywords: PTSD, resting state networks, с-fos, spontaneous behavior, protein synthesis inhibition.