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JOURNALS // Izvestiya of Saratov University. Physics // Archive

Izv. Sarat. Univ. Physics, 2011 Volume 11, Issue 2, Pages 62–66 (Mi isuph117)

This article is cited in 2 papers

Physics

Morphological changes in the internal organs of laboratory animals under a single administration of Fe nanoparticles

N. A. Navolokina, O. V. Matveevaa, G. N. Maslyakovaa, A. B. Bucharskayaa, L. V. Suleymanovaa, X. M. Konga, B. A. Medvedevb, A. A. Ignatievb, Ò. V. Bochkaryevab

a Saratov State Medical University named after V. I. Razumovsky
b Saratov State University

Abstract: The cytotoxic effect of iron nanoparticles of size of 70 nm was studied in an experiment with single intramuscular and oral administration in albino mice and rats. Morphological changes were assessed in the internal organs, brain and the injection site. Studies had shown that intramuscular changes are more pronounced than when nanoparticles were administered orally and were shown in signs of cell damage while after the oral administration the blood flow changes in vessels were noted.

Keywords: nanoparticles, iron, toxicity, nanotoxicity.

UDC: 537.622.4:57.085:591.4:599.323.4:576.6;576.33:577.29:615

DOI: 10.18500/1817-3020-2011-11-2-62-66



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