Decrease of low-frequency spectral power in a heart rate variability signal in a mathematical model of the cardiovascular system of arterial hypertension patients

Background and Objectives: Index equal to the spectral power of the low-frequency oscillations from the time series of the time intervals between the hearts contractions are often used when investigating the cardiovascular system. Experimental studies have shown that this spectral index was a preclinical marker of cardiovascular diseases, including arterial hypertension and diabetes. However, physiological understanding of this index, in particular, its relation to the tone of autonomic control is still largely not understood. Materials and Methods: This problem was studied using mathematical models of the cardiovascular system, which simulated a healthy subject and an arterial hypertension patient. Conclusion: The decrease in the power of low-frequency oscillations in the time-series of the time intervals between the heart contractions in arterial hypertension patients was due to decreased dynamic range of the arterial baroreceptors.