N. A. Navolokin, G. N. Maslyakova, A. B. Bucharskaya, L. V. Suleymanova, X. M. Kong, G. S. Terentyuk, N. G. Khlebtsov, B. N. Khlebtsov, “Dynamics of morphological and biochemical changes in laboratory animals with transplanted kidney cancer after intravenous injection of gold nanoshells”, Izv. Sarat. Univ. Physics, 2012, Volume 12, Issue 2,Pages <nobr>38

Physics

Dynamics of morphological and biochemical changes in laboratory animals with transplanted kidney cancer after intravenous injection of gold nanoshells

N. A. Navolokin^a, G. N. Maslyakova^a, A. B. Bucharskaya^a, L. V. Suleymanova^a, X. M. Kong^a, G. S. Terentyuk^a, N. G. Khlebtsov^b, B. N. Khlebtsov^b

^a Saratov State Medical University
^b Institute of Biochemistry and Physiology of Plants and Microorganisms RAS

Abstract: The effect of intravenously injected nanoshells on white outbred male rats with transplanted tumor of kidney cancer was studied. The blood biochemical parameters and morphological changes in the rat internal organs were examined during 24 h after nanoparticle injection. The most pronounced changes were observed 45 min - 2 h after nanoparticle injection and were reversible.

Keywords: nanoparticles, gold nanoshells, toxicity, morphology, biochemistry, transplanted cancer, kidney cancer.

UDC: 57.08:577.29:615: 576.6; 576.33: 616-091.8572:616.716.8(571.5)

DOI: 10.18500/1817-3020-2012-12-2-38-43