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JOURNALS // Izvestiya of Saratov University. Physics // Archive

Izv. Sarat. Univ. Physics, 2021 Volume 21, Issue 3, Pages 213–221 (Mi isuph17)

Biophysics and Medical Physics

The method for diagnostics of the phase synchronization of the vegetative control of blood circulation in real time

A. V. Kurbakoa, E. I. Borovkovaabc, A. R. Kiselevacd, V. V. Skazkinaa, V. I. Ponomarenkoab, B. P. Bezruchkoab, A. S. Karavaevabe

a Saratov State University, 83 Astrakhanskaya St., Saratov 410012, Russia
b Saratov Branch of Kotel’nikov Institute of Radio Engineering and Electronics of the Russian Academy of Sciences, 38 Zelenaya St., Saratov 410019, Russia
c Saratov State Medical University named after V. I. Razumovsky, 112 Bolshaya Kazachya St., Saratov 410012, Russia
d National Medical Research Center for Therapy and Preventive Medicine, 10 building 3, Petroverigsky lane, Moscow 101990, Russia
e University Innopolis, 1 Universitetskaya St., Innopolis city 420500, Russia

Abstract: Background and Objectives: The development of methods for the analysis of non-stationary signals of biological nature makes it possible to solve a number of fundamental and applied problems. The use of these methods is promising for the diagnosis and prevention of diseases of the cardiovascular system. The creation of the device makes it possible to detect diseases at an early stage. However, this requires the development of methods for analyzing non-stationary signals of biological nature in real time. Therefore, the purpose of the study is the method for diagnosing the phase chain of autonomic control of blood circulation in real time. Materials and Methods: Test realizations of instantaneous phase differences were created, repeating the statistical properties of real data recorded from people. A comparison of the sensitivity of the developed and known methods for different values of the input parameters was carried out. The complexity of the two methods was estimated. Results: A method was developed for diagnosing the phase chains of autonomic control of blood circulation in real time. The methods showed similar sensitivity values. The developed method has less complexity in comparison with the known method. Conclusion: The developed method can be used to diagnose the phase synchronization of the autonomic regulation circuits of the heart and blood vessels in real time.

Keywords: phase synchronization, sensitivity, specificity, time series, baroreflex regulation, heart rate variability.

UDC: 530.182:537.86

Received: 20.04.2021

DOI: 10.18500/1817-3020-2021-21-3-213-221



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