E. V. Navrotskaya, A. S. Karavaev, M. V. Sinkin, E. I. Borovkova, B. P. Bezruchko, “Adaptation of the method of coupling analysis based on phase dynamics modeling to EEG signals during an epileptic seizure in comatose patients”, Izv. Sarat. Univ. Physics, 2022, Volume 22, Issue 1,Pages <nobr>4

Biophysics and Medical Physics

Adaptation of the method of coupling analysis based on phase dynamics modeling to EEG signals during an epileptic seizure in comatose patients

E. V. Navrotskaya^ab, A. S. Karavaev^ba, M. V. Sinkin^c, E. I. Borovkova^ba, B. P. Bezruchko^ab

^a Saratov Branch of the Institute of Radioengineering and Electronics of Russian Academy of Sciences
^b Saratov State University
^c N.V. Sklifosovsky Research Institute of Emergency Medicine

Abstract: Background and Objectives: the coupling of EEG signals during an epileptic seizure in patients during coma is being studied. Materials and Methods: the analysis of the applicability of the method of detecting the interaction between oscillatory systems based on the phase dynamics modeling to EEG signals during an epilepsy seizure in comatose patients is carried out. Results: a method of preliminary filtering of EEG signals has been proposed and the values of the method parameters have been selected, which allow obtaining reliable estimates of directional coupling at a significance level of 0.05. As an example, the analysis of the couplings between EEG signals of two patients with the mentioned pathologies was carried out using the method of the coupling estimation developed in this work.

Keywords: EEG, epilepsy, coma, phase, phase dynamics modeling, coupling estimation, coupling direction, statistical significance, time series analysis, mean phase coherence.

UDC: 530.18

Received: 01.10.2021

DOI: 10.18500/1817-3020-2022-22-1-4-14