Abstract:Background and Objectives: Based on polymers and inorganic components, hybrid nanostructured materials are used in biomedicine, including tissue engineering and drug delivery withthe controlled release. This research aimsto developthemethodforforming composite coating of vaterite and MNPs on electrospun PCL fibers, which will maintain sensitivity to magnetic fields for a period for the use of magnetotherapy and to control the rate of drug release. Materials and Methods: Three methods of CaCO$_3$ + magnetic nanoparticles coating formation on the surface of policaprolacton fibers were tested. The coating recrystallization time of CaCO$_3$ (transformation from the vaterite polymorph to calcite) on policaprolacton fibers was determined. Results: For samples obtained by CaCO$_3$ and magnetite coprecipitation and US-assisted methods, the time of complete recrystallization is 5 hours, which is less by 2 times than the recrystallization rate of the control sample. Conclusion: The crystallization-induced method is most effective, proved by the recrystallization time of magnetic CaCO$_3$ microparticles on the surface of PCL fibers, which is comparable to the control sample. Obtained by the method of salt co-precipitation with magnetite and US-assisted method, inorganic coatings on PCL fibers have a shorter recrystallization period.
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