A. S. Moskvin, A. M. Ryvkin, O. E. Solovyova, V. S. Markhasin, “Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating”, Pis'ma v Zh. Èksper. Teoret. Fiz., 2011, Volume 93, Issue 7,Pages <nobr>446

This article is cited in 12 papers

BIOPHYSICS

Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating

A. S. Moskvin^a, A. M. Ryvkin^b, O. E. Solovyova^ba, V. S. Markhasin^b

^a Ural State University
^b Institute of Immunology and Physiology, Ural Branch of RAS

Abstract: We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca$^{2+}$ SR overload.

Received: 23.12.2010
Revised: 21.02.2011

Language: English