Oscillatory kinetics of gene transcription during the cellular growth

The negative feedback between mRNA and regulatory-protein production may result in oscillations in the kinetics of gene transcription. If the mRNA and/or protein number are low, the oscillations may be irregular. We present mean-field calculations and Monte-Carlo simulations showing evolution of such oscillations during the cellular growth and division. The oscillations are found to be fairly stable with respect to the cellular growth.