A. S. Chizhikova, E. B. Yudina, A. M. Panich, M. Salti, Yu. V. Kulvelis, A. I. Shames, O. Prager, E. Swissa, A. E. Aleksenskii, A. Ya. Vul', “Diamond nanoparticles as a contrast agent for MRI”, Zhurnal Tekhnicheskoi Fiziki, 2024, Volume 94, Issue 9,Pages <nobr>1474

Specialized issue based on the materials of the V International Conference ''Physics - life Sciences'' St. Petersburg, October 15-19, 2023
Nanomaterials and nanodiagnostics in biology and medicine

Diamond nanoparticles as a contrast agent for MRI

A. S. Chizhikova^a, E. B. Yudina^a, A. M. Panich^b, M. Salti^c, Yu. V. Kulvelis^d, A. I. Shames^b, O. Prager^e, E. Swissa, A. E. Aleksenskii^a, A. Ya. Vul'^a

^a Ioffe Institute, St. Petersburg
^b Department of Physics, Ben-Gurion University of the Negev, 8410501 Beer-Sheva, Israel
^c Brain Imaging Research Center, Ben-Gurion University of the Negev, 8410501 Beer-Sheva, Israel
^d The Petersburg Nuclear Physics Institute, The National Research Center "Kurchatov Institute"
^e Brain and Cognitive Sciences, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 8410501 Beer-Sheva, Israel

Abstract: The effectiveness of detonation nanodiamonds with a surface modified with manganese (ND–Mn) and gadolinium (ND-Gd) ions in application as contrast agents for magnetic resonance imaging is studied. The use of polyvinylpyrrolidone as a stabilizing agent prevents the agglomeration of particles in saline solution. According to the method of nuclear magnetic resonance, the ND–Mn and ND–Gd particles in saline hydrosols increase the rates of spin-lattice and spin-spin relaxation of protons in the hydrosol.

Keywords: magnetic resonance imaging, nuclear magnetic resonance, detonation nanodiamonds, gadolinium, manganese.

Received: 02.03.2024
Revised: 20.06.2024
Accepted: 16.07.2024

DOI: 10.61011/JTF.2024.09.58667.70-24