Study of characteristics of magnetic nanoparticles produced by laser ablation

The article presents the results of magnetic nanoparticles studies for biomedical applications. Nanoparticles were synthesized by laser ablation in deionized water and acetone with subsequent magnetic separation. Raman spectroscopy indicates the predominance of magnetite particles among the obtained material. Scanning electron microscopy studies indicate a spherical shape of the particles, their size is 70 nm when synthesized in deionized water and 64 nm when synthesized in acetone. The cytotoxicity of nanoparticles was studied for connective tissue cells and tumor cells using a colorimetric test for assessing cell activity and fluorescence microscopy. It was found that nanoparticles are non-toxic for healthy cells, while a decrease in the number of tumor cells is achieved at a colloidal solution concentration of nanoparticles of more than 1.7$\mu$g/ml, the creation of nanoparticles in acetone and transfer to a non-toxic solvent does not reduce the survival of cells. The results of the study indicate the prospects for the use of synthesized nanoparticles for biomedical applications related to theranostics of socially significant diseases.