Elena O. Kutumova, Andrey Y. Zinovyev, Ruslan N. Sharipov, Fedor A. Kolpakov, “The Application of Model Reduction Methods to the Construction of the Composite Model of Apoptotic Pathways”, Mat. Biolog. Bioinform., 2012, Volume 7, Issue 2,Pages <nobr>572

Bioinformatics

The Application of Model Reduction Methods to the Construction of the Composite Model of Apoptotic Pathways

Elena O. Kutumova^ab, Andrey Y. Zinovyev^cd, Ruslan N. Sharipov^be, Fedor A. Kolpakov^ab

^a Design Technological Institute of Digital Techniques, The Siberian Branch of The Russian Academy of Sciences, Novosibirsk 630090, Russia
^b Institute of Systems Biology, Ltd, Novosibirsk 630090, Russia
^c Institut Curie, Paris F-75248, France
^d Institute of Computational modelling, The Siberian Branch of The Russian Academy of Sciences, Krasnoyarsk 660036, Russia
^e Institute of Cytology and Genetics, The Siberian Branch of The Russian Academy of Sciences, Novosibirsk 630090, Russia

Abstract: We propose a new approach to composition of mathematical models of biological systems, based on their reduction. This approach has been tested on the example of two apoptosis models describing pro- and anti-apoptotic (activation of NF-$\kappa$B) pathways of CD95.

Key words: mathematical modeling, model reduction, CD95-induced apoptosis, transcription factor NF-$\kappa$B, BioUML.

UDC: 51-76

Received 02.10.2012, Published 01.11.2012