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Mat. Biolog. Bioinform., 2007 Volume 2, Issue 1, Pages 66–72 (Mi mbb18)

Proceedings of The International Conference "Mathematical Biology and Bioinformatics"

A stochastic model of the intracellular dynamics of the multicopy bacterial plasmids subject to control of replication

A. N. Shuvaeva, A. V. Bril'kovb

a Institute of Biophysics Siberian Branch of RAS
b Siberian Federal University

Abstract: The dynamics of the bacterial plasmids was investigated in case of small shifts from the stationary state. By shifts we understand the alteration of the plasmid copy number from the stationary value. The Fokker–Planck approximation for one-step processes was used here. The dynamics was found to happen in Ornstein–Uhlenbeck form. The research data allows us to predetermine that hyperbolic inhibition mechanism describes the plasmid replication control process in a good way.

Key words: plasmids, replication control, one-step process, Ornstein–Uhlenbeck process, Fokker–Planck equation.

UDC: 576.538:579.252.5:51-76

Received 29.03.2007, Published 24.04.2007



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