V. V. Pelipko, I. A. Litvinov, E. O. Sinegubova, V. V. Zarubaev, R. I. Baichurin, S. V. Makarenko, “2-[2-(Phenylcarbamoyl)hydrazinylidene]propanoates: synthesis, structure and <i>in vitro</i> study of the activity against influenza virus”, Mendeleev Commun., 2024, Volume 34, Issue 2,Pages <nobr>259

This article is cited in 2 papers

Communications

2-[2-(Phenylcarbamoyl)hydrazinylidene]propanoates: synthesis, structure and in vitro study of the activity against influenza virus

V. V. Pelipko^a, I. A. Litvinov^b, E. O. Sinegubova^c, V. V. Zarubaev^c, R. I. Baichurin^a, S. V. Makarenko^a

^a Herzen State Pedagogical University of Russia, St. Petersburg, Russian Federation
^b A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, Kazan, Russian Federation
^c St. Petersburg Pasteur Institute, St. Petersburg, Russian Federation

Abstract: Alkyl (2E)-2-[2-(phenylcarbamoyl)hydrazinylidene]- propanoates were prepared from 3-nitroacrylates and N-phenylhydrazinecarboxamide. Their fine structure was confirmed by NMR and X-ray data. Cytotoxicity and antiviral activity against the A/Puerto Rico/8/34 (H1N1) influenza virus strain in MDCK cell culture were determined for the obtained compounds.

Keywords: nitroacrylates, N-phenylhydrazinecarboxamide, nucleophilic addition, aza-Michael adduct, hydrazone, influenza A (H1N1) virus, biological activity.

Language: English

DOI: 10.1016/j.mencom.2024.02.031

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