Mendeleev Commun., 2021 Volume 31, Issue 5, Pages 659–661
(Mi mendc1014)
This article is cited in
10 papers
Communications Liposomes loaded with lipophilic derivative of closo-carborane as a potential boron delivery system for boron neutron capture therapy of tumors A. R. Tsygankova ab ,
D. A. Gruzdev cd ,
V. V. Kanygin a ,
T. Ya. Guselnikova ab ,
A. A. Telegina cd ,
A. I. Kasatova ae ,
A. I. Kichigin a ,
G. L. Levit c ,
L. V. Mechetina f ,
R. A. Mukhamadiyarov g ,
I. A. Razumov ah ,
O. I. Solovieva h ,
O. Yu. Volkova f ,
A. A. Ponomarev h ,
V. P. Krasnov cd ,
E. L. Zavjalov ah a Novosibirsk State University, Novosibirsk, Russian Federation b A.V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation c I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation d Institute of Chemical Engineering, Ural Federal University, Ekaterinburg, Russian Federation e G.I. Budker Institute of Nuclear Physics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
f Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
g Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation
h Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation Abstract:
Liposomes encapsulated with lipophilic derivative of 1,2-dicarba-closo-dodecaborane have been obtained and tested for toxicity to glioblastoma U87 cells and biodistribution on a U87MG xenograft mouse model. The liposomes are able to penetrate the tumor and provide boron concentration up to 1.5 mmmmg g–1 with tumor-to-muscle ratio up to 2.4.
Keywords:
amide, closo-carborane, liposomes, U87 tumor model, toxicity, biodistribution, BNCT.
Language: English
DOI:
10.1016/j.mencom.2021.09.022
© , 2025
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