S. A. Zakharenkova, V. V. Abzianidze, N. I. Moiseeva, D. S. Lukina, L. S. Chistyi, D. V. Krivorotov, Yu. G. Trishin, “Antitumor activity of phaeosphaeride A modified with nitrogen heterocyclic groups”, Mendeleev Commun., 2021, Volume 31, Issue 5,Pages <nobr>662

This article is cited in 4 papers

Communications

Antitumor activity of phaeosphaeride A modified with nitrogen heterocyclic groups

S. A. Zakharenkova^a, V. V. Abzianidze^a, N. I. Moiseeva^b, D. S. Lukina^a, L. S. Chistyi^a, D. V. Krivorotov^a, Yu. G. Trishin^c

^a Research Institute of Hygiene, Occupational Pathology and Human Ecology, Leningrad region, Russian Federation
^b N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation
^c Saint-Petersburg State University of Industrial Technologies and Design, St. Petersburg, Russian Federation

Abstract: New C(6)-derivatives of natural phaeosphaeride A (PPA) modified with pharmacophoric nitrogen heterocyclic groups have been synthesized. The reaction of 1,2,4-triazole with PPA mesylate produced both the product of the expected substitution of the methanesulfonate group and the PPA derivative with two 1,2,4-triazole groups: at the C(6) atom and the exocyclic C=C bond. The synthesized compounds, with the exception of those containing two 1,2,4-triazole groups, are superior in cytotoxic activity to the original phaeosphaeride and the positive control, etoposide.

Keywords: antitumor activity, phaeosphaeride A, N-heterocyclic compounds, sulfides, natural products, in vitro studies, anticancer agents, etoposide.

Language: English

DOI: 10.1016/j.mencom.2021.09.023

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