L. K. Kibardina, A. V. Trifonov, A. B. Dobrynin, M. A. Pudovik, A. R. Burilov, A. D. Voloshina, A. G. Strelnik, A. S. Gazizov, “Anticancer activity of novel 3-azaxanthenes”, Mendeleev Commun., 2021, Volume 31, Issue 5,Pages <nobr>664

This article is cited in 3 papers

Communications

Anticancer activity of novel 3-azaxanthenes

L. K. Kibardina, A. V. Trifonov, A. B. Dobrynin, M. A. Pudovik, A. R. Burilov, A. D. Voloshina, A. G. Strelnik, A. S. Gazizov

A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, Kazan, Russian Federation

Abstract: Novel 3-azaxanthenes have been synthesized via acid-catalyzed one-pot Friedel–Crafts reaction of pyridoxal/pyridoxal-5'-phosphate with naphthols followed by dehydration of the intermediate bis(2-hydroxyaryl)-(pyridin-4-yl)methane derivatives. The cytotoxicity of the obtained 3-azaxanthenes against M-HeLa and HuTu-80 tumor cell lines is comparable to that of tamoxifen, whereas the cytotoxicity against normal cell line is absent in the tested concentrations range, which makes this class of compounds interesting for further studies.

Keywords: 3-azaxanthenes, chromeno[2, 3-c]pyridines, pyridoxal, naphthol, cyclization, cytotoxicity, anticancer activity.

Language: English

DOI: 10.1016/j.mencom.2021.09.024

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