Sh. M. Sanad, A. E. Mekky, “Synthesis and antibacterial evaluation of new pyrido[3',2':4,5]thieno[3,2-d ]pyrimidin-4(3H)-one hybrids linked to different heteroarene units”, Mendeleev Commun., 2021, Volume 31, Issue 6,Pages 862

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Communications

Synthesis and antibacterial evaluation of new pyrido[3',2':4,5]thieno[3,2-d ]pyrimidin-4(3H)-one hybrids linked to different heteroarene units

Sh. M. Sanad, A. E. Mekky

Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt

Abstract: A three-component protocol involving the reaction of 3-aminothieno[2,3-b]pyridine-2-carboxylate, Me₂NCH(OMe)₂ and heteroaryl (bis)amines in dioxane under microwave irradiation yielded a new series of pyrimidinones. The target hybrids were formed by an initial formamidine formation,Pyrazole-linked pyrimidinones displayed the best antibacterial activity against all the gram-positive and negative strains tested.

Keywords: cross-imidination, formamidines, [5+1] heterocyclization, in vitro antibacterial screening, microwave-assisted reactions, multicomponent reactions, pyrimidinones, tandem reactions, thieno[2,3-b]pyridines.

Language: English

DOI: 10.1016/j.mencom.2021.11.031

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