V. V. Abzianidze, Yu. V. Chelusnova, G. V. Karakashev, D. M. Kochura, M. A. Leninskii, A. Yu. Gorbunov, M. D. Shachneva, D. V. Krivorotov, A. I. Ukolov, “Synthesis of a tripeptide biomarker of exposure to sulfur mustard for support of OPCW biomedical proficiency tests”, Mendeleev Commun., 2021, Volume 31, Issue 6,Pages <nobr>867

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Communications

Synthesis of a tripeptide biomarker of exposure to sulfur mustard for support of OPCW biomedical proficiency tests

V. V. Abzianidze, Yu. V. Chelusnova, G. V. Karakashev, D. M. Kochura, M. A. Leninskii, A. Yu. Gorbunov, M. D. Shachneva, D. V. Krivorotov, A. I. Ukolov

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Leningrad region, Russian Federation

Abstract: S-[2-(2-Hydroxyethylthio)ethyl]-Cys-Pro-Phe (HETE–CPP) was synthesized in seven steps as a reference compound for the development of a procedure for its quantification in blood plasma in the OPCW biomedical proficiency tests.

Keywords: OPCW, sulfur mustard, positive control, qualitative and quantitative analysis, collision-induced dissociation, sulfides, peptide synthesis, tripeptides.

Language: English

DOI: 10.1016/j.mencom.2021.11.033

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