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JOURNALS // Mendeleev Communications // Archive

Mendeleev Commun., 2021 Volume 31, Issue 6, Pages 899–901 (Mi mendc1081)

This article is cited in 1 paper

Communications

Easy size control of polymer nanoparticles obtained by emulsification–evaporation technique in a microfluidic reactor

M. A. Merkulova, N. S. Osipova, O. O. Maksimenko, M. G. Gordienko, S. E. Gelperina

D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation

Abstract: The production of polymer nanoparticles with a narrow size distribution on standard T- and X-configuration microfluidic chips with a channel size of 100 μm has been achieved. Introducing ethanol into the aqueous phase in 1:9 ratio (v/v) allowed one to reduce the surface tension of the contacting phases and obtain nanoparticles in the range of 100–150 nm. This makes our approach promising for development of nanoscale drug delivery systems.

Keywords: microfluidics, interfacial tension, emulsification–evaporation method, poly(lactide-co-glycolide) nanoparticles, drug delivery systems.

Language: English

DOI: 10.1016/j.mencom.2021.11.044



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