S. V. Kurmaz, N. V. Fadeeva, B. S. Fedorov, G. I. Kozub, N. S. Emelyanova, V. A. Kurmaz, R. A. Manzhos, A. A. Balakina, A. A. Terentyev, “New antitumor hybrid materials based on PtIV organic complex and polymer nanoparticles consisting of N-vinylpyrrolidone and (di)methacrylates”, Mendeleev Commun., 2020, Volume 30, Issue 1,Pages 22

This article is cited in 20 papers

Communications

New antitumor hybrid materials based on Pt^IV organic complex and polymer nanoparticles consisting of N-vinylpyrrolidone and (di)methacrylates

S. V. Kurmaz^a, N. V. Fadeeva^a, B. S. Fedorov^a, G. I. Kozub^ab, N. S. Emelyanova^c, V. A. Kurmaz^a, R. A. Manzhos^a, A. A. Balakina^ab, A. A. Terentyev^ab

^a Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^b Moscow Region State Pedagogical University, Mytishi, Moscow Region, Russian Federation
^c Department of Physical and Chemical Engineering, M.V. Lomonosov Moscow State University, Moscow, Russian Federation

Abstract: New cis-bis[N-(2-nitroxyethyl)isonicotinamide-N]platinum(iv) tetrachloride hybrid materials were obtained via its solubilization by nanoparticles of N-vinylpyrrolidone copolymer with dimethacrylates and characterized. The materials containing 2% of PtIV complex cause a cytotoxic effect on the tumor A-172 cells; IC50 values were ca. 106μm after incubation for 48h.

Keywords: N-vinylpyrrolidone, (di)methacrylates, amphiphilic copolymers, polymer particles, platinum(iv) organic complex, hybrid materials, cytotoxicity, antitumor activity.

Language: English

DOI: 10.1016/j.mencom.2020.01.007

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