N. N. Sudareva, O. M. Suvorova, I. I. Tarasenko, N. N. Saprykina, N. V. Smirnova, S. G. Petunov, A. S. Radilov, A. S. Timin, E. G. Korzhikova-Vlakh, A. D. Vilesov, “Hybrid systems for oral delivery of a therapeutic neuropeptide”, Mendeleev Commun., 2020, Volume 30, Issue 1,Pages <nobr>25

This article is cited in 9 papers

Communications

Hybrid systems for oral delivery of a therapeutic neuropeptide

N. N. Sudareva^ab, O. M. Suvorova^a, I. I. Tarasenko^a, N. N. Saprykina^a, N. V. Smirnova^a, S. G. Petunov^cd, A. S. Radilov^c, A. S. Timin^b, E. G. Korzhikova-Vlakh^a, A. D. Vilesov^ab

^a Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, Russian Federation
^b I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation
^c Research Institute of Hygiene, Occupational Pathology and Human Ecology, Leningrad region, Russian Federation
^d I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russian Federation

Abstract: Several hybrid systems for oral delivery of a therapeutic peptide have been prepared and investigated. Poly(l-glutamic acidco-d-phenylalanine) and silica sub-microparticles, porous CaCO₃ microparticles and Lycopodium clavatum spore capsules were employed as the first level carriers included in sodium alginate granules as the second level carriers. Efficiency of the peptide encapsulation and release rate strongly depended on the nature and structure of the carriers.

Keywords: peptide delivery systems, encapsulation, alginate granules, poly(amino acids), silica and CaCO₃ sub-microparticles, sporopollenin exine capsules.

Language: English

DOI: 10.1016/j.mencom.2020.01.008

	*Supplementary materials:*
		Supplementary_data_1.pdf	805.5 Kb