A. V. Kalistratova, L. V. Kovalenko, M. S. Oshchepkov, A. M. Gamisoniya, T. S. Gerasimova, Yu. A. Demidov, M. G. Akimov, “Synthesis of new compounds in the series of aryl-substituted ureas with cytotoxic and antioxidant activity”, Mendeleev Commun., 2020, Volume 30, Issue 2,Pages <nobr>153

This article is cited in 9 papers

Communications

Synthesis of new compounds in the series of aryl-substituted ureas with cytotoxic and antioxidant activity

A. V. Kalistratova^a, L. V. Kovalenko^a, M. S. Oshchepkov^a, A. M. Gamisoniya^b, T. S. Gerasimova^a, Yu. A. Demidov^a, M. G. Akimov^b

^a D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
^b M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: A series of aryl-substituted ureas and carbamates containing chlorinated aromatic and modified imidazolidinone moieties were synthesized. These compounds were found to be cytotoxic to breast cancer cell line MDA-MB-231, glioblastoma U-87 MG and neuroblastoma SH-SY5Y, but not to melanoma A-375.

Keywords: synthetic cytokinins, substituted ureas, anti-stress effect, cytotoxicity, oxidative stress..

Language: English

DOI: 10.1016/j.mencom.2020.03.007

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