N. S. Kuzmina, V. F. Otvagin, L. V. Krylova, A. V. Nyuchev, Yu. V. Romanenko, O. I. Koifman, I. V. Balalaeva, A. Yu. Fedorov, “Synthesis and antiproliferative activity of new chlorin e6 glycoconjugates”, Mendeleev Commun., 2020, Volume 30, Issue 2,Pages 159

This article is cited in 13 papers

Communications

Synthesis and antiproliferative activity of new chlorin e₆ glycoconjugates

N. S. Kuzmina^a, V. F. Otvagin^a, L. V. Krylova^a, A. V. Nyuchev^a, Yu. V. Romanenko^b, O. I. Koifman^b, I. V. Balalaeva^a, A. Yu. Fedorov^a

^a N.I. Lobachevsky State University of Nizhni Novgorod, Nizhni Novgorod, Russian Federation
^b Research Institute of Macroheterocycles, Ivanovo State University of Chemistry and Technology, Ivanovo, Russian Federation

Abstract: New water soluble conjugates of chlorin e₆ derivative–zinc complex with β-d-galactose or β-d-glucose have been synthesized as potential agents for the photodynamic therapy of cancer. They exhibit photoinduced cytotoxicity at low micromolar concentrations with IC_50(dark)/IC_50(light) ratio of ∼50.

Keywords: chlorin e₆, glycoconjugate, water soluble, A431 cells, photodynamic therapy.

Language: English

DOI: 10.1016/j.mencom.2020.03.009

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