E. G. Paronikyan, Sh. Sh. Dashyan, S. S. Mamyan, “Synthesis of pyrano[3,4-c]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyridines, representatives of a new fused heterocyclic system”, Mendeleev Commun., 2020, Volume 30, Issue 2,Pages 183

This article is cited in 4 papers

Communications

Synthesis of pyrano[3,4-c]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyridines, representatives of a new fused heterocyclic system

E. G. Paronikyan, Sh. Sh. Dashyan, S. S. Mamyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia

Abstract: New effective synthesis of functionalized pyrano[3,4-c]thieno-[3,2-e][1,2,4]triazolo[4,3-a]pyridines comprises nucleophilic substitution in 8-morpholino-6-thioxopyrano[3,4-c]pyridine-5-carbonitrile with hydrazine hydrate followed by sequential heterocyclization with formic acid and chloroacetic acid derivatives.

Keywords: pyrano[3,4-c]pyridines, triazolo[4,3-a]pyridines, pyrano[3,4-c]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyridines, hydrazines, thiones, heterocyclization, alkylation.

Language: English

DOI: 10.1016/j.mencom.2020.03.017

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