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JOURNALS // Mendeleev Communications // Archive

Mendeleev Commun., 2020 Volume 30, Issue 4, Pages 424–426 (Mi mendc1211)

This article is cited in 17 papers

Communications

Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer

A. N. Vereshchagina, N. A. Frolova, V. Yu. Konyuhovaa, E. O. Dorofeevaa, K. A. Hansfordb, M. P. Egorova

a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
b Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia

Abstract: Novel bis-quaternary ammonium compounds with a p-terphenyl spacer between two pyridinium heads were synthesized. Hit compound with C8H17 aliphatic substituent is superior to known benzalkonium chloride, miramistin and chlorhexidine bisgluconate in MIC values against five pathogenic bacteria.

Keywords: bis-quaternary ammonium compounds, pyridinium salts, terphenyls, alkylation, antibacterial agents, fungicides, antifungal activity, methicillin resistance, Staphylococcus aureus.

Language: English

DOI: 10.1016/j.mencom.2020.07.006



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