A. N. Vereshchagin, N. A. Frolov, V. Yu. Konyuhova, E. O. Dorofeeva, K. A. Hansford, M. P. Egorov, “Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with <i>p</i>-terphenyl spacer”, Mendeleev Commun., 2020, Volume 30, Issue 4,Pages <nobr>424

This article is cited in 17 papers

Communications

Synthesis and biological evaluation of novel bis-quaternary ammonium compounds with p-terphenyl spacer

A. N. Vereshchagin^a, N. A. Frolov^a, V. Yu. Konyuhova^a, E. O. Dorofeeva^a, K. A. Hansford^b, M. P. Egorov^a

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia

Abstract: Novel bis-quaternary ammonium compounds with a p-terphenyl spacer between two pyridinium heads were synthesized. Hit compound with C₈H₁₇ aliphatic substituent is superior to known benzalkonium chloride, miramistin and chlorhexidine bisgluconate in MIC values against five pathogenic bacteria.

Keywords: bis-quaternary ammonium compounds, pyridinium salts, terphenyls, alkylation, antibacterial agents, fungicides, antifungal activity, methicillin resistance, Staphylococcus aureus.

Language: English

DOI: 10.1016/j.mencom.2020.07.006

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