I. G. Mamedov, F. N. Naghiev, A. M. Maharramov, O. Uwangue, A. Farewell, P. Sunnerhagen, M. Erdelyi, “Antibacterial activity of 2-amino-3-cyanopyridine derivatives”, Mendeleev Commun., 2020, Volume 30, Issue 4,Pages <nobr>498

This article is cited in 20 papers

Communications

Antibacterial activity of 2-amino-3-cyanopyridine derivatives

I. G. Mamedov^a, F. N. Naghiev^a, A. M. Maharramov^a, O. Uwangue^b, A. Farewell^b, P. Sunnerhagen^b, M. Erdelyi^c

^a Department of Chemistry, Baku State University, Baku, Azerbaijan
^b Department of Chemistry and Molecular Biology and the Center for Antibiotic Resistance Research (CARe), University of Gothenburg, Gothenburg, Sweden
^c Department of Chemistry, Uppsala University, Uppsala, Sweden

Abstract: New 2-amino-4-aryl-3-cyanopyridines were obtained by the three-component condensation of arylidenemalononitriles, malononitrile and (di)amine system or acetoacetanilide. Antibacterial activity of all synthesized compounds against the Gram-negative bacteria E. coli and the Gram-positive B. subtilis was tested, the only representative showed a substantial antimicrobial effect.

Keywords: 3,5-dicyanopyridines, antimicrobial activity, halogen bonding, bacteria, E. coli, B. subtilis.

Language: English

DOI: 10.1016/j.mencom.2020.07.031

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