K. S. Egorova, A. V. Posvyatenko, A. S. Galushko, A. E. Kolesnikov, “Comparison of assessments of overall toxicity of chemical reactions upon using cytotoxicity and acute toxicity data”, Mendeleev Commun., 2024, Volume 34, Issue 3,Pages <nobr>351

Communications

Comparison of assessments of overall toxicity of chemical reactions upon using cytotoxicity and acute toxicity data

K. S. Egorova^a, A. V. Posvyatenko^ab, A. S. Galushko^a, A. E. Kolesnikov^a

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation

Abstract: In this work, by means of bio-Strips and toxicity potentials, we compare the results of analysis of toxic potentials of chemical reactions when using cytotoxicity or acute toxicity data. Here, 24 routes of synthesis of 1,1’-biphenyl are used for exemplary purposes.

Keywords: C–C cross-coupling, 11’-biphenyl, acute toxicity, cytotoxicity, rat, cell culture, bio-Profile, bio-Strip, toxicity potential.

Language: English

DOI: 10.1016/j.mencom.2024.04.013

	*Supplementary materials:*
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