A. E. Varakutin, E. A. Muravsky, I. Yu. Shinkarev, V. N. Khrustalev, V. V. Semenov, “Hydrogenation of plant polyalkoxybenzene derivatives: convenient access to coenzyme Q<sub>0</sub> analogues”, Mendeleev Commun., 2020, Volume 30, Issue 5,Pages <nobr>599

This article is cited in 6 papers

Communications

Hydrogenation of plant polyalkoxybenzene derivatives: convenient access to coenzyme Q₀ analogues

A. E. Varakutin^a, E. A. Muravsky^b, I. Yu. Shinkarev^b, V. N. Khrustalev^ac, V. V. Semenov^a

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b D.Mendeleev University of Chemical Technology of Russia, Moscow, Russian Federation
^c Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation

Abstract: A technologically advanced protocol has been developed for converting plant allyl(polyalkoxy)benzenes to methyl- and propyl(polyalkoxy)benzenes being intermediates in the syntheses of coenzyme Q₀ analogues. The key stage of allyl and benzaldehyde moieties hydrogenation was carried out in a periodical autoclave mode on highly porous ceramic block Pd-catalysts. These catalysts possess large surface area, low hydraulic resistance, significant thermal and mechanical stabililty, multiple cycling and easy regeneration, which can dramatically reduce Pd consumption.

Keywords: coenzyme Q₀, antioxidants, ceramic block catalysts, palladium catalysts, hydrogenation, alkyl(polyalkoxy)benzenes.

Language: English

DOI: 10.1016/j.mencom.2020.09.015

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