M. P. Paramonova, R. Snoeck, G. Andrei, A. L. Khandazhinskaya, M. S. Novikov, “New acetamide derivatives containing (ω-p-bromophenoxyalkyl)uracil moiety and their anticytomegalovirus activity”, Mendeleev Commun., 2020, Volume 30, Issue 5,Pages <nobr>602

This article is cited in 9 papers

Communications

New acetamide derivatives containing (ω-p-bromophenoxyalkyl)uracil moiety and their anticytomegalovirus activity

M. P. Paramonova^a, R. Snoeck^b, G. Andrei^b, A. L. Khandazhinskaya^c, M. S. Novikov^a

^a Volgograd State Medical University, Volgograd, Russian Federation
^b Rega Institute for Medical Research, Leuven, Belgium
^c V.A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: New N-aryl-2-{3-[ω-(4-bromophenoxy)alkyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}acetamides have been obtained from 1-[ω-(4-bromophenoxy)alkyl]uracil and 2-chloro-N-(4-phenoxyphenyl)acetamide derivatives. Investigation of their antiviral properties against human cytomegalovirus revealed that the representative with dodecane-1,12-diyl linker exhibited powerful virus inhibitory activity in vitro.

Keywords: human cytomegalovirus, uracil derivative, acetamide, diaryl oxide, bromoarene, antiviral activity.

Language: English

DOI: 10.1016/j.mencom.2020.09.016

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