D. A. Khochenkov, Yu. A. Khochenkova, Yu. S. Machkova, R. E. Gasanov, E. V. Stepanova, A. S. Bunev, “Synthesis and cytotoxic activity of novel 4-amino-5-cyano-2-sulfonylpyrimidines”, Mendeleev Commun., 2020, Volume 30, Issue 5,Pages <nobr>604

This article is cited in 2 papers

Communications

Synthesis and cytotoxic activity of novel 4-amino-5-cyano-2-sulfonylpyrimidines

D. A. Khochenkov^ab, Yu. A. Khochenkova^b, Yu. S. Machkova^b, R. E. Gasanov^a, E. V. Stepanova^b, A. S. Bunev^a

^a Medicinal Chemistry Centre, Togliatti State University, Togliatti, Russian Federation
^b N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation

Abstract: Novel 4-amino-5-cyano-2-sulfonylpyrimidines were prepared based on three-component cyclization between isothiouronium salts, benzaldehydes and malononitrile, followed by oxidation of the sulfide moiety with Oxone. The cytotoxic activity of the synthesized compounds, as well as the induction of apoptosis, inhibition of the cell cycle and proliferation tests were performed on selected cancer cell lines A431, A549, A375, HCT 116, MCF7, LNCap and SH-SY5Y.

Keywords: heterocyclization, pyrimidines, isothiouronic salts, nitriles, sulfones, cytotoxic activity, cancer cell lines.

Language: English

DOI: 10.1016/j.mencom.2020.09.017

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