J. Matthews, P. N. Veremeeva, E. A. Golubeva, M. I. Lavrov, E. V. Radchenko, M. A. Topchiy, V. L. Zamoyski, V. V. Grigoriev, V. A. Palyulin, “7-Benzyl-1,5-dimethyl-3-piperonyloyl-3,7-diazabicyclo[3.3.1]nonan-9-one as an allosteric modulator of glutamatergic system”, Mendeleev Commun., 2024, Volume 34, Issue 3,Pages <nobr>354

This article is cited in 1 paper

Communications

7-Benzyl-1,5-dimethyl-3-piperonyloyl-3,7-diazabicyclo[3.3.1]nonan-9-one as an allosteric modulator of glutamatergic system

J. Matthews^a, P. N. Veremeeva^a, E. A. Golubeva^a, M. I. Lavrov^a, E. V. Radchenko^a, M. A. Topchiy^b, V. L. Zamoyski^c, V. V. Grigoriev^ac, V. A. Palyulin^a

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russian Federation
^c Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation

Abstract: The title compound has been synthesized and assessed in vitro by means of electrophysiological patch clamp technique revealing a positive modulatory effect on the kainate-induced currents in Purkinje neurons in a wide concentration range from 10^–12 to 10^–6 m. Molecular docking and molecular dynamics simulation revealed a putative binding mode of this compound in the binding site of positive allosteric modulators of AMPA receptors.

Keywords: 3,7-diazabicyclo[3.3.1]nonanes, piperonylic acid, AMPA receptor, allosteric modulators, PAMs, patch clamp.

Language: English

DOI: 10.1016/j.mencom.2024.04.014

	*Supplementary materials:*
		Supplementary_data_1.pdf	779.4 Kb